Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, RAS
Laboratory of Biomolecular NMR Spectroscopy
Structure and function of proteins, ion channels and toxins at atomic resolution, by high-resolution nuclear magnetic resonance.
Transmembrane domain of APP, solved in the laboratory by NMR · PDB 2LOH · drag to rotate
Research
Membrane and membrane-active proteins
Membrane proteins and receptors
TM domains of receptor tyrosine kinases, toll-like receptors, GPCRs; dimerisation of transmembrane helices.
Ion channels
Structural basis of conduction and its modulation.
Amyloid precursor protein
Role of APP TM-domain dimerisation in Alzheimer's disease.
Neurotoxins
Toxins from snake, insect and spider venoms as modulators of channels and receptors.
Antimicrobial peptides
Channel-forming peptides and their mechanisms of action.
Plant defence peptides
Hevein-like peptides, lipid-transfer proteins, protease inhibitors.